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NAM Aidsmap: "Contraception."

Rodriguez M.D., Maria Isabel "What medications mess with birth control?"

DeRossi, S.S. Dental Clinics of North America, October 2002.

McKinley Health Center, University of Illinois, "Pill Interactions With Other Drugs"

Weisberg, E. Clinical Pharmacokinetics, May 1999.

U.S. National Library of Medicine: "Griseofulvin," "Ketoconazole," "St. buy augmentin 875 mg John's Wort," "Saw palmetto," "Garlic," "Alfalfa," "Flaxseed." Doodipala, S. Expert Review of Clinical Pharmacology, March 1, 2010.

Epilepsy Foundation: "Women FAQ."

Robertson P. Clinical Pharmacology and Therapeutics, January 2002.

Narcolepsy UK: "All you need to know about modafinil and the pill."

Stanford Medicine: "Psychiatric Medications, Modafinil"

National Center for Complementary and Integrative Health: "Questions and Answers: A Trial of St. John's Wort (Hypericum perforatum) for the Treatment of Major Depression."

Metabolism And Excretion

The half life of amoxicillin after the oral administration of AUGMENTIN is 1.3 hours and that of clavulanic acid is 1 hour.

Approximately 50% to 70% of the amoxicillin and approximately 25% to 40% of the clavulanic acid are excreted unchanged in urine during the first 6 hours after administration of a single 250 mg or 500 mg tablet of AUGMENTIN.


Broad spectrum antibiotics can lead to lower levels of circulating oral contraceptive hormone levels and have, thus, been implicated in causing failures in women taking oral contraceptives (10). Failure of oral contraceptive steroids can lead to several outcomes, including breakthrough bleeding, pregnancy and menstrual abnormalities such as amenorrhea and spotting (11). Intermenstrual bleeding is often considered a clinical sign of oral contraceptive failure if it has not been experienced by the patient before with a particular medication (11).

Clinical Trial Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

The most frequently reported adverse reactions were diarrhea/loose stools (9%), nausea (3%), skin rashes and urticaria (3%), vomiting (1%) and vaginitis (1%). Less than 3% of patients discontinued therapy because of drug related adverse reactions. The overall incidence of adverse reactions, and in particular diarrhea, increased with the higher recommended dose. Other less frequently reported adverse reactions (<1%) include: Abdominal discomfort, flatulence, and headache.

In pediatric patients (aged 2 months to 12 years), 1 US/Canadian clinical trial was conducted which compared 45/6.4 mg/kg/day (divided every 12 hours) of AUGMENTIN for 10 days versus 40/10 mg/kg/day (divided every 8 hours) of AUGMENTIN for 10 days in the treatment of acute otitis media. A total of 575 patients were enrolled, and only the suspension formulations were used in this trial. Overall, the adverse reactions seen were comparable to that noted above; however, there were differences in the rates of diarrhea, skin rashes/urticaria, and diaper area rashes. [See Clinical Studies]

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Haunter of Dreams PAGE 12


Azithromycin is the active substance of the following antibacterial drugs:

By the mechanism of action, analogues of azithromycin are:


  • Lecoclar;
  • Clarithromycin;
  • Oleandomycin;
  • Fromilide;
  • Rovamycin Spiramycin Vero;
  • Macropen;
  • Erythromycin.



The use of azithromycin is contraindicated in case of hypersensitivity to macrolide antibiotics. Caution is necessary when prescribing the drug to patients with liver or kidney dysfunction, as well as with a history of allergic reactions.

The active substance crosses the placenta, therefore, during pregnancy, the drug is prescribed only in cases where the potential benefits of the application outweigh the risk to the fetus. azithromycin online Breastfeeding for the treatment period is stopped.


The domestic manufacturer's antibiotic is Pharmstandard-Leksredstva OJSC. Capsules contain 250 mg or 500 mg of azithromycin. Patients older than 12 years take the drug 2 hours before or after meals, observing the daily break between use. Indications for use:


  • respiratory diseases - 0.5 g per day for 3 days;
  • infections of the urinary system and genitals - immediately take 1 g (2 pieces of 0.5 g each);
  • infection of the skin, purulent inflammation - 1 g on the first day of treatment, then 0.5 g for another 4 days.


The average packaging price of 6 pieces of 250 mg each is about 301 rubles, 2 capsules of 500 mg - 247 rubles, 3 capsules of 500 mg - 350 rubles..,

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Meloxicam injections, instructions for use

The drug in the form of a solution of Meloxicam DS is prescribed to adolescents and adults from 15 years of age at 7.5 mg or 15 mg once a day deeply intramuscularly for the first few days of treatment. meloxicam no prescription For therapy, it is more advisable to use oral forms of the drug.

Price and special instructions

The cost of the drug Meloxicam in tablets of 15 mg No. 20 is about 60 rubles. The price of injections 10 mg No. 3 - from 160 rubles.

The medicine is dispensed from pharmacies by prescription. Keep it away from children in a dark and cool place. The expiration date of the drug is indicated on the package, after its use is strictly contraindicated.

The medicine is prescribed with caution in case of previously transferred diseases of the kidneys and liver. Before treatment, it is recommended to undergo a second examination to exclude problems with the lungs and heart. The entire period of therapy, the patient should be under the supervision of a physician. For people at risk (with kidney failure and the elderly), the dosage is selected individually, and the condition is constantly monitored by taking blood and urine tests.

When combining medication with a diuretic, patients are advised to consume more fluid. Simultaneous treatment with antihypertensive drugs can lead to a decrease in their effectiveness, therefore a dosage change is required. The combination with anticoagulants is dangerous, since there is a likelihood of complications.

Meloxicam is not recommended to be combined with other drugs from the group of non-steroidal anti-inflammatory drugs. This can become a factor in the occurrence of gastritis and exacerbation of peptic ulcer of the stomach and duodenum..

To reduce the irritating effect on the walls of the stomach, it is advisable to drink the tablets with milk. Taking medication can affect your attention span, which must be considered when driving a car..


Dosage and administration

Intramuscular administration of the drug is indicated only during the first 2-3 days. Further treatment is continued with the use of oral forms (tablets). The recommended dose is 7.5 mg or 15 mg 1 time per day, depending on the intensity of the pain and the severity of the inflammatory process. The maximum recommended daily dose is 15 mg. The drug is administered by deep intramuscular injection. Considering possible incompatibility, meloxicam should not be mixed in the same syringe with other drugs. In patients with an increased risk of adverse reactions and with severe renal failure on hemodialysis, the dose should not exceed 7.5 mg per day. For patients with mild or moderate renal failure (creatinine clearance greater than 30 ml / min), dose adjustment is not required. The drug can not be administered intravenously. Combined use. You should not use the drug simultaneously with other NSAIDs. The total daily dose of meloxicam used in the form of tablets, suppositories, suspension for oral administration and injection, should not exceed 15 mg..


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